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Can you take Tylenol with prednisone? Safety and drug interactions

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Tylenol (acetaminophen) is commonly used to relieve pain and control fever.

Prednisone is a prescription drug that reduces swelling, irritation, and inflammation associated with a wide range of conditions.

Tylenol and prednisone are not known to interact with each other and are generally safe to take together as long as you stick to the recommended doses. However, they can interact with other drugs.

Read on to learn more about when you can take Tylenol with prednisone and what precautions you should take.

Tylenol is one of the most popular drugs in the United States. It is estimated that approximately 1 of 5 American adults take a medicine that contains the active ingredient acetaminophen in a given week.

Prednisone is only available with a prescription and belongs to a class of drugs called corticosteroids. These types of drugs can help reduce inflammation in the body.

What is Tylenol used for?

Acetaminophen works by blocking chemicals in your brain that carry pain signals. Tylenol and other forms of acetaminophen are commonly used to relieve fever and pain caused by conditions such as:

What is prednisone used for?

Prednisone is only available with a prescription and is used to treat a variety of conditions by reducing inflammation and suppressing the activity of the immune system.

Some of the common conditions for which doctors prescribe prednisone include:

Tylenol and prednisone are not known to interact with each. They are generally safe to take together, as long as you do not take more than the recommended doses. It is important to follow the directions on the package or the instructions given by your doctor.

In general, it is best to take only one new medicine at a time to see how one medicine affects you before taking another. It is also a good idea to check with a healthcare practitioner each time you combine medications.

Although taking Tylenol and prednisone are not known to cause negative interactions, they can interact with other medicines.

Tylenol is not the only medicine that contains acetaminophen. Many other medicines also contain acetaminophen.

This is why it is important to check the labels of any other medication you are taking to make sure it does not contain acetaminophen. If so, you may take more acetaminophen than the recommended daily dose.

Some other medicines containing acetaminophen include:

  • generic acetaminophen
  • NyQuil
  • Day
  • Sudafed PE Sinus Pressure + Pain
  • Panadol Extra Strong

Tylenol is known to interact with many types of drugs. Some of these interactions can lead to serious complications. That is why it is a good idea to always speak with your doctor before combining Tylenol with other medicines.

Some classes of drugs that Tylenol is known to interact with include:

Prednisone is known to interact with hundreds of types of drugs. Some of the drugs it may interact with include:

Most people do not experience any side effects when taking the recommended dose of Tylenol. Rarely, people develop an allergic reaction which can cause symptoms such as:

  • bulbs
  • urticaria
  • itching
  • swelling of the tongue, lips, face, or throat
  • difficulty breathing and swallowing

Taking more than the recommended dose of Tylenol can lead to liver damage. Acetaminophen is responsible for approximately 500 deaths per year in the United States However, liver damage is rare if you follow the recommended dose.

Symptoms of liver damage can include:

The risk of side effects from prednisone increases with the amount you take.

Common Side effects of prednisone include:

  • weight gain
  • digestive problems
  • insomnia
  • commotion
  • sweat more than usual

Less common side effects include:

In rare cases, it is also possible to develop a severe allergic reaction to prednisone.

When taking Tylenol, it is a good idea to:

  • Check your other medications for acetaminophen when calculating your daily dose.
  • Follow the directions on the label or the directions given by your doctor.
  • Do not exceed the daily limit written on the label. According to the makers of Tylenol, the maximum daily dose of single ingredient Tylenol Extra Strength sold in the United States has been lowered from 4000 mg to 3000 mg.
  • Minimize alcohol consumption and avoid consuming more than three drinks per day.
  • If you have had liver disease, consult a healthcare practitioner before taking Tylenol.

When taking prednisone you are advised to:

  • Tell your doctor if you have a known allergy to other medicines.
  • Tell your doctor about all prescription and over-the-counter medications you take, including vitamin and herbal supplements.
  • Tell your doctor if you are pregnant or plan to become pregnant.
  • Stay away from sick people – prednisone can make you more vulnerable to infections.
  • Tell your doctor if you have a current eye infection or chronic infections.
  • Talk to your doctor before getting vaccinated.

Tylenol and prednisone are generally safe to take together and are not known to interact with each other. However, the two drugs can interact with other types of drugs.

It is important not to take more than the maximum recommended dose of either drug. Consult your doctor or health care professional before combining Tylenol or prednisone with any new medicines or supplements.


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